2008 Woodie Awards
Gene changes affect lung cancer recurrence
Issue date: 4/3/08
The methylation profiles of seven genes were obtained, and four genes in particular were observed to have large differences in distribution of methylation in the tissue samples. Of these four genes, p16 and CDH13 were associated with a significant chance of recurrence.
The survival rate of patients without methylation in any of the four genes was 27.3 percent. Methylation of both p16 and CDH13 in the tumor and the mediastinal lymph nodes, which are located in the chest between the two lungs, yielded a low survival rate of 14.3 percent.
The study indicated that modification of certain genes in specific tissues is associated with recurrence of a tumor.
This study also demonstrates that patients could have microscopic disease in apparently normal lymph nodes and not have any clinical symptoms until it's too late.
Furthermore, success in this research provides a new assay for evaluation of disease recurrence and survival rate in non-small-cell lung cancer patients.
The survival rate of patients without methylation in any of the four genes was 27.3 percent. Methylation of both p16 and CDH13 in the tumor and the mediastinal lymph nodes, which are located in the chest between the two lungs, yielded a low survival rate of 14.3 percent.
The study indicated that modification of certain genes in specific tissues is associated with recurrence of a tumor.
This study also demonstrates that patients could have microscopic disease in apparently normal lymph nodes and not have any clinical symptoms until it's too late.
Furthermore, success in this research provides a new assay for evaluation of disease recurrence and survival rate in non-small-cell lung cancer patients.
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